Effects of green synthesized calcium oxide nanoparticles from extracts of Citrullus colocynthis on body weight, plasma atherogenic index, and histology of liver and stomach of high-fat-diet-fed rats

Citrullus colocynthis has been used to treat obesity and hyperlipidemia. Nanoparticles, due their nano size, phytochemical adsorption, improved systemic absorption high bioavailability, can potentially improve the bioactivity of C. colocynthis. The present research focused on studying effects green synthesized calcium oxide nanoparticles (CaONPs) from fruit extracts (CCFE) body weight, atherogenic index plasma (AIP), histopathology male albino rats. Ethyl??-d-glucopyranoside was major constituent CCFE, along with phenols fatty acids. total phenolic flavonoid contents CCFE were 203.52 173.56 mg/g, respectively. Male rats (n=36) divided into six groups (six per each group). Rats in different received a normal diet, high?fat diet (HFD), HFD lovastatin (10 mg/kg), (20 CaONPs (2 synergistic solution mg/kg) (1 When administered combination significant weight-lowering activity (36.36%), cardiovascular health as AIP (0.12?0.01b), fewer disturbances liver function parameters observed. Histological analysis at end experiment showed that not toxic gastric mucosa slightly hepatocytes. It be concluded potent antilipidemic agent side effects.